度鲁特韦
| CAS号 | 1051375-16-6 | 货号 | BCP02329 |
| 中文名 | 度鲁特韦 | ||
| 英文名 | Dolutegravir | ||
| 中文别名 | 德罗特韦;多替拉韦;杜鲁特韦;多特格伟; | ||
| 英文别名 | GSK1349572;GSK 1349572;GSK-1349572;S/GSK1349572;S-349572; | ||
| 分子式 | C20H19F2N3O5 | 分子量 | 419.38 |
| 生物活性 | Dolutegravir is an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication. | ||
| 信号通路 | Protease/Metabolic Enzyme Microbiology/Virology | ||
| 靶 点 | Integrase HIV | ||
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Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study
购于瀚香生物(Biochempartner)的度鲁特韦(CAS:1051375-16-6)被引用 |
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Development and validation of LC–MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study
购于瀚香生物(Biochempartner)的度鲁特韦(CAS:1051375-16-6)被引用 |
结构式
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