BSI-401
| CAS号 | 142404-10-2 | 货号 | BCP27642 |
| 中文名 | BSI-401 | ||
| 英文名 | BSI-401 | ||
| 中文别名 | |||
| 英文别名 | BSI401;BSI 401; | ||
| 分子式 | C9H4INO4 | 分子量 | 317.04 |
| 生物活性 | BSI-401 is a novel PARP-1 inhibitor with both oral bioavailability and strong antitumor potency. The IC50 of BSI-401 for all of the five pancreatic cancer cell lines was <15 μM. BSI-401 inhibits the growth of pancreatic cancer cells in vitro significantly. BSI-401 inhibits low-anchorage tumor cell colony formation. BSI-401 combined with oxaliplatin had potent synergistic antitumor activity (46 versus 132 days, P = 0.0063), and significantly (P = 0.0148) prevented acute oxaliplatin-induced neurotoxicity. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | PARP | ||
结构式
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