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| CAS号 | 142404-10-2 | 货号 | BCP27642 |
| 中文名 | BSI-401 | ||
| 英文名 | BSI-401 | ||
| 中文别名 | |||
| 英文别名 | BSI401;BSI 401; | ||
| SMILES | C1=CC(=O)OC2=C1C(=C(C=C2)[N+](=O)[O-])I | ||
| 化学名称 | |||
| 分子式 | C9H4INO4 | 分子量 | 317.04 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | BSI-401 is a novel PARP-1 inhibitor with both oral bioavailability and strong antitumor potency. The IC50 of BSI-401 for all of the five pancreatic cancer cell lines was <15 μM. BSI-401 inhibits the growth of pancreatic cancer cells in vitro significantly. BSI-401 inhibits low-anchorage tumor cell colony formation. BSI-401 combined with oxaliplatin had potent synergistic antitumor activity (46 versus 132 days, P = 0.0063), and significantly (P = 0.0148) prevented acute oxaliplatin-induced neurotoxicity. | ||
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