环磷酰胺
| CAS号 | 50-18-0 | 货号 | BCP02139 |
| 中文名 | 环磷酰胺 | ||
| 英文名 | Cyclophosphamide | ||
| 中文别名 | |||
| 英文别名 | Cyclophosphane; | ||
| 分子式 | C7H15Cl2N2O2P | 分子量 | 261.09 |
| 生物活性 | Cyclophosphamide is an alkylating agent with cytotoxic and immunosuppressive activities. Cyclophosphamide requires enzymatic and chemical activation to release active phosphoramide mustard which produces the interstrand and intrastrand DNA crosslinks at guanine N-7 positions. Cyclophosphamide exerts its cytotoxic activity by inhibiting nuclear DNA replication. The mechanism of Cyclophosphamide -induced immunosuppression is possibly due to direct cytotoxic effect of the drug on immunocompetent lymphocytes, particulafly those that have undergone antigenic differentiation and division. Cyclophosphamide has its greatest effect on B cells with relative T cell-sparing effect. [1] Trials in various tumor-bearing animals confirmed this in vivo activity and demonstrated fairly potent antitumor effect. Cyclophosphamide, in combination with other antineoplastic agents, is used for the treatment of various cancers, including breast, lymphoid and pediatric malignancies. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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