环磷酰胺

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02139CAS号：50-18-0纯度：98%

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CAS号	50-18-0	货号	BCP02139
中文名	环磷酰胺
英文名	Cyclophosphamide
中文别名
英文别名	Cyclophosphane;
SMILES
化学名称
分子式	C7H15Cl2N2O2P	分子量	261.09
纯度	98%	配送	惯例下常温包邮
产品描述	Cyclophosphamide is an alkylating agent with cytotoxic and immunosuppressive activities. Cyclophosphamide requires enzymatic and chemical activation to release active phosphoramide mustard which produces the interstrand and intrastrand DNA crosslinks at guanine N-7 positions. Cyclophosphamide exerts its cytotoxic activity by inhibiting nuclear DNA replication. The mechanism of Cyclophosphamide -induced immunosuppression is possibly due to direct cytotoxic effect of the drug on immunocompetent lymphocytes, particulafly those that have undergone antigenic differentiation and division. Cyclophosphamide has its greatest effect on B cells with relative T cell-sparing effect. [1] Trials in various tumor-bearing animals confirmed this in vivo activity and demonstrated fairly potent antitumor effect. Cyclophosphamide, in combination with other antineoplastic agents, is used for the treatment of various cancers, including breast, lymphoid and pediatric malignancies.