BMS-536924
| CAS No. | 468740-43-4 | Cat. No. | BCP02116 |
| Name | BMS-536924 | ||
| Synonyms | BMS536924;BMS 536924; | ||
| Formula | C25H26ClN5O3 | M. Wt | 479.96 |
| Description | BMS-536924 also inhibits FAK and Lck with IC50 of 150 nM and 341 nM, respectively. BMS-536924 inhibits cellular proliferation and disrupts Akt and MAPK phosphorylation.BMS-536924 inhibits IGF-I-stimulated IGF-1R signaling in MCF10A cells and blocks constitutive IGF-1R activity in CD8-IGF-1R-MCF10A. Preincubation of MCF10A cells with 1 μM BMS-536924 completely blocks the ability of IGF-I to stimulate IGF-1R phosphorylation. IGF-I stimulation results in increased phosphorylation of ERK1/2, GSK3β, and Akt. BMS-536924 inhibits this ligand-induced phosphorylation. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Insulin Receptor IGF1R | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.