BMS-536924
Data Sheet
For research use only. Not for human use.
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| CAS No. | 468740-43-4 | Cat. No. | BCP02116 |
| Name | BMS-536924 | ||
| Synonyms | BMS536924;BMS 536924; | ||
| SMILES | O=C1C(C2=NC3=C(C)C=C(N4CCOCC4)C=C3N2)=C(NC[C@H](C5=CC=CC(Cl)=C5)O)C=CN1 | ||
| Chemical Name | |||
| Formula | C25H26ClN5O3 | M. Wt | 479.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-536924 also inhibits FAK and Lck with IC50 of 150 nM and 341 nM, respectively. BMS-536924 inhibits cellular proliferation and disrupts Akt and MAPK phosphorylation.BMS-536924 inhibits IGF-I-stimulated IGF-1R signaling in MCF10A cells and blocks constitutive IGF-1R activity in CD8-IGF-1R-MCF10A. Preincubation of MCF10A cells with 1 μM BMS-536924 completely blocks the ability of IGF-I to stimulate IGF-1R phosphorylation. IGF-I stimulation results in increased phosphorylation of ERK1/2, GSK3β, and Akt. BMS-536924 inhibits this ligand-induced phosphorylation. | ||
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