Avasimibe
CAS No. | 166518-60-1 | Cat. No. | BCP02302 |
Name | Avasimibe | ||
Synonyms | CI-1011;CI1011;CI 1011;PD-148515;PD148515;PD 148515; | ||
Formula | C29H43NO4S | M. Wt | 501.72 |
Description | Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model. | ||
Pathways | Protease/Metabolic Enzyme | ||
Targets | DGAT |
Structure
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