PF-562271
| CAS号 | 717907-75-0 | 货号 | BCP01852 |
| 中文名 | PF-562271 | ||
| 英文名 | PF-562271 | ||
| 中文别名 | |||
| 英文别名 | PF562271;PF00562271; | ||
| 分子式 | C21H20F3N7O3S | 分子量 | 507.49 |
| 生物活性 | PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. | ||
| 上下游产品 | 939791-38-5（PF 562271 苯磺酸盐） 939791-41-0（PF562271 HCl） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FAK | ||
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Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer
购于瀚香生物(Biochempartner)的PF-562271(CAS:717907-75-0)被引用 |
结构式
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