Masitinib
| CAS No. | 790299-79-5 | Cat. No. | BCP01820 |
| Name | Masitinib | ||
| Synonyms | AB1010;Masivet;AB-1010;AB 1010; | ||
| Formula | C28H30N6OS | M. Wt | 498.65 |
| Description | Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | PDGFR c Kit FAK | ||
Structure
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