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CAS No. | 790299-79-5 | Cat. No. | BCP01820 |
Name | Masitinib | ||
Synonyms | AB1010;Masivet;AB-1010;AB 1010; | ||
SMILES | O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4 | ||
Chemical Name | |||
Formula | C28H30N6OS | M. Wt | 498.65 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). |
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