MG-132
| CAS号 | 133407-82-6 | 货号 | BCP02537 |
| 中文名 | MG-132 | ||
| 英文名 | MG-132 | ||
| 中文别名 | |||
| 英文别名 | MG132;MG 132; | ||
| 分子式 | C26H41N3O5 | 分子量 | 475.62 |
| 生物活性 | MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. | ||
| 上下游产品 | 1211877-36-9（(R)-MG-132） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Proteasome | ||
结构式
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