MG-132 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02537CAS号：133407-82-6纯度：98%

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CAS号	133407-82-6	货号	BCP02537
关联产品	1211877-36-9（(R)-MG-132）
中文名	MG-132
英文名	MG-132
中文别名
英文别名	MG132;MG 132;
SMILES	O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C=O)=O)=O
化学名称
分子式	C26H41N3O5	分子量	475.62
纯度	98%	配送	惯例下常温包邮
产品描述	MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.