Vanoxerine dihydrochloride

CAS No.	67469-78-7	Cat. No.	BCP02306
Name	Vanoxerine dihydrochloride
Synonyms	GBR-12909 dihydrochloride; GBR12909 dihydrochloride; GBR 12909 dihydrochloride;
Formula	C28H32F2N2O.2(HCl)	M. Wt	523.49

Description	GBR-12909 is a potent dopamine transport blocker studied extensively in rats. By inhibiting DAT function, GBR-12909 was able to induce a bipolar disorder mania-like phenotypes in mice. Also shown to cause postnatal changes to produce useful ADHD animal models. GBR-12909 caused an increase in core body temperature when administered to serotonin transporter knockout mice. Reportedly mimics cocaine-mediated enhancement of Tat neurotoxicity in rat midbrain primary cell cultures.
Pathways	Neuro Signaling Pathway
Targets	Dopamine Transporter

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