NVP-BHG712
| CAS No. | 940310-85-0 | Cat. No. | BCP02362 |
| Name | NVP-BHG712 | ||
| Synonyms | NVP-BHG 712;NVP BHG 712; BHG-712; BHG712; BHG 712; | ||
| Formula | C26H20F3N7O | M. Wt | 503.48 |
| Description | In a growth factor-induced angiogenesis model, NVP-BHG712 (3 mg/kg, p.o) significantly suppresses VEGF stimulated tissue formation and vascularization by inhibiting EphB4 forward signaling. Furthermore, NVP-BHG712 (10 mg/kg/kg, p.o.) potently reverses VEGF enhanced tissue formation and vessel growth. NVP-BHG712 (3 mg/kg, p.o.) shows a long lasting exposure with concentrations around 10 μM in plasma as well as in lung and liver tissue for up to 8 hours, and thus results in a long lasting inhibition of EphB4 kinase activity in mice. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Ephrin Receptor Src/Bcr Abl VEGFR | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.