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NVP-BHG712 Chemical Structure

NVP-BHG712

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02362CAS No. ：940310-85-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 940310-85-0 Cat. No. BCP02362
Name NVP-BHG712
Synonyms NVP-BHG 712;NVP BHG 712; BHG-712; BHG712; BHG 712;
SMILES
Chemical Name
Formula C26H20F3N7O M. Wt 503.48
Purity 98% Storage Store at 4-8°C
Description In a growth factor-induced angiogenesis model, NVP-BHG712 (3 mg/kg, p.o) significantly suppresses VEGF stimulated tissue formation and vascularization by inhibiting EphB4 forward signaling. Furthermore, NVP-BHG712 (10 mg/kg/kg, p.o.) potently reverses VEGF enhanced tissue formation and vessel growth. NVP-BHG712 (3 mg/kg, p.o.) shows a long lasting exposure with concentrations around 10 μM in plasma as well as in lung and liver tissue for up to 8 hours, and thus results in a long lasting inhibition of EphB4 kinase activity in mice.
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