双盐酸诺拉曲塞
| CAS号 | 152946-68-4 | 货号 | BCP02372 |
| 中文名 | 双盐酸诺拉曲塞 | ||
| 英文名 | Nolatrexed dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | Nolatrexed 2HCl;AG 337 2HCl;AG-337 2HCl;AG337 2HCl; | ||
| 分子式 | C14H12N4OS·2(HCl) | 分子量 | 357.26 |
| 生物活性 | Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Thymidylate Synthase | ||
结构式
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