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Thymidylate Synthase

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Thymidylate Synthase

结构式 货号 产品名称 CAS号
Nolatrexed dihydrochloride 结构式
 BCP02372 双盐酸诺拉曲塞 152946-68-4
Nolatrexed dihydrochloride is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells.
Tipiracil HCl 结构式
 BCP06245 盐酸替吡嘧啶 183204-72-0
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Tipiracil 结构式
 BCP24231 替吡嘧啶 183204-74-2
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
Raltitrexed 结构式
 BCP02874 雷替曲塞 112887-68-0
Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. Raltitrexed is used as an antimetabolite drug used in the treatment of colorectal cancer, and may be beneficial for malignant mesothelioma treatment.
Trifluridine 结构式
 BCP09147 曲氟胸苷 70-00-8
Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
TAS-102 结构式
 BCP28532 TAS-102 733030-01-8
TAS-102 is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase inhibitor, tipiracil, in a 1:0.5 molar ratio.
Nolatrexed 结构式
 BCP12638 诺拉曲特 147149-76-6
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity.
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