NMS-873
| CAS No. | 1418013-75-8 | Cat. No. | BCP08666 |
| Name | NMS-873 | ||
| Synonyms | NMS873;NMS 873; | ||
| Formula | C27H28N4O3S2 | M. Wt | 520.67 |
| Description | NMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor) with IC50 of 30 nM. NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | p97 | ||
Structure
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