Chk2 Inhibitor II
| CAS No. | 516480-79-8 | Cat. No. | BCP09077 |
| Name | Chk2 Inhibitor II | ||
| Synonyms | BML277; BML-277; BML 277; | ||
| Formula | C20H14ClN3O2 | M. Wt | 363.8 |
| Description | BML-277 (Chk2 Inhibitor II) is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. This is suggestive of BML-277's use as an adjuvant for radiation therapy in cancer. BML-277 is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. It has also been found to weakly inhibit 31 other kinases. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Checkpoint | ||
Structure
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