Trifluridine

CAS No.	70-00-8	Cat. No.	BCP09147
Name	Trifluridine
Synonyms	FTD;Viroptic;Trifluorothymidine;NSC 529182;NSC 75520;NSC-75520;
Formula	C10H11F3N2O5	M. Wt	296.2

Description	in vitro: When HeLa cells were treated with TFT at a concentration of 1 uM (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT . SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) . in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed .
Related Products	733030-01-8（Trifluridine-tipiracil hydrochloride mixture）
Pathways	Cell Cycle/DNA Damage Apoptosis Pathway
Targets	Thymidylate Synthase Antimetabolite

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