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Trifluridine Chemical Structure

Trifluridine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP09147CAS No. :70-00-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 70-00-8 Cat. No. BCP09147
Related Products 733030-01-8(Trifluridine-tipiracil hydrochloride mixture)
Name Trifluridine
Synonyms FTD;Viroptic;Trifluorothymidine;NSC 529182;NSC 75520;NSC-75520;
SMILES
Chemical Name
Formula C10H11F3N2O5 M. Wt 296.2
Purity 98% Storage Store at 4-8°C
Description in vitro: When HeLa cells were treated with TFT at a concentration of 1 uM (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT . SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) . in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed .
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