LY900009
| CAS号 | 209984-68-9 | 货号 | BCP27986 |
| 中文名 | LY900009 | ||
| 英文名 | LY900009 | ||
| 中文别名 | |||
| 英文别名 | LY-900009; LY 900009; | ||
| 分子式 | C23H27N3O4 | 分子量 | 409.48 |
| 生物活性 | LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. LY900009 inhibited plasma levels of amyloid-β peptide in a dose-dependent manner with 80-90% inhibition observed in the 30- to 60-mg cohorts. LY900009 is an orally available GSI (Aβ: IC50= 10.9−12.1 nM; Notch: IC50 = 14.1 nM) that was developed as a candidate therapeutic drug against AD (IDENTITY trial), which failed in phase III trials. | ||
| 信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| 靶 点 | Gamma secretase | ||
结构式
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