TAK960
| CAS No. | 1137868-52-0 | Cat. No. | BCP09476 |
| Name | TAK960 | ||
| Synonyms | TAK-960;TAK 960; | ||
| Formula | C27H34F3N7O3 | M. Wt | 561.6 |
| Description | TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PLK | ||
Structure
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