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TAK960 Chemical Structure

TAK960

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP09476CAS No. ：1137868-52-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1137868-52-0 Cat. No. BCP09476
Name TAK960
Synonyms TAK-960;TAK 960;
SMILES
Chemical Name
Formula C27H34F3N7O3 M. Wt 561.6
Purity 98% Storage Store at 4-8°C
Description TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis.
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