PF 915275
| CAS No. | 857290-04-1 | Cat. No. | BCP28049 |
| Name | PF 915275 | ||
| Synonyms | PF-915275; PF915275; | ||
| Formula | C18H14N4O2S | M. Wt | 350.39 |
| Description | PF-915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) PF-915275 inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | 11β HSD | ||
Structure
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