Rolapitant

CAS No.	552292-08-7	Cat. No.	BCP09609
Name	Rolapitant
Synonyms	(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one;
Formula	C25H26F6N2O2	M. Wt	500.48

Description	. In vitro studies indicate that rolapitant has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold. Rolapitant is a functionally competitive antagonist, as measured by calcium efflux, with a calculated Kb of 0.17 nM.
Pathways	GPCR/G Protein
Targets	NK Receptor

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