Guadecitabine
| CAS No. | 929901-49-5 | Cat. No. | BCP28067 |
| Name | Guadecitabine | ||
| Synonyms | SGI110; SGI-110; SGI 110; S110; | ||
| Formula | C18H24N9O10P | M. Wt | 557.41 |
| Description | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. | ||
| Pathways | Epigenetics | ||
| Targets | DNA Methyltransferase | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.