Guadecitabine New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 929901-49-5 | Cat. No. | BCP28067 |
| Name | Guadecitabine | ||
| Synonyms | SGI110; SGI-110; SGI 110; S110; | ||
| SMILES | C1C(C(OC1N2C=NC3=C2NC(=NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)O | ||
| Chemical Name | |||
| Formula | C18H24N9O10P | M. Wt | 557.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. | ||
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