LB42708
| CAS No. | 226929-39-1 | Cat. No. | BCP09683 |
| Name | LB42708 | ||
| Synonyms | LB-42708; LB 42708; | ||
| Formula | C30H27BrN4O2 | M. Wt | 555.46 |
| Description | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | FTase | ||
Structure
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