LB42708 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 226929-39-1 | Cat. No. | BCP09683 |
| Name | LB42708 | ||
| Synonyms | LB-42708; LB 42708; | ||
| SMILES | C1COCCN1C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC=C(C=C6)Br | ||
| Chemical Name | |||
| Formula | C30H27BrN4O2 | M. Wt | 555.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. | ||
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