AZ20
| CAS No. | 1233339-22-4 | Cat. No. | BCP09895 |
| Name | AZ20 | ||
| Synonyms | AZ-20;AZ 20; | ||
| Formula | C21H24N4O3S | M. Wt | 412.51 |
| Description | in vitro: AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases H2AX pan-nuclear staining, indicative of replication stress. in vivo: AZ20 induces significant tumour growth inhibition in vivo at well tolerated doses. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | ATM/ATR | ||
Structure
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