OTSSP167
| CAS No. | 1431697-89-0 | Cat. No. | BCP09935 |
| Name | OTSSP167 | ||
| Synonyms | OTSSP-167;OTSSP 167; OTS167; OTS-167; OTS 167; | ||
| Formula | C25H28Cl2N4O2 | M. Wt | 486.16 |
| Description | OTSSP167 is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. | ||
| Related Products | 1431698-10-0（OTSSP167 hydrochloride） | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | MELK | ||
Structure
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