BQ-788 Sodium
| CAS No. | 156161-89-6 | Cat. No. | BCP28133 |
| Name | BQ-788 Sodium | ||
| Synonyms | BQ-788 sodium salt ;BQ788; BQ-788; BQ 788; | ||
| Formula | C34H50N5O7.Na | M. Wt | 663.79 |
| Description | BQ-788 (sodium salt) is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.BQ788 is a endothelin B receptor antagonist. BQ788 attenuates stab wound injury-induced reactive astrocytes in rat brain. BQ788 were well tolerated and showed signs of directly and indirectly reducing the viability of melanoma cells. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Endothelin Receptor | ||
Structure
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