SAR125844

  • Chemical Properties
CAS No. 1116743-46-4 Cat. No. BCP28183
Name SAR125844
Synonyms SAR 125844; SAR-125844;
Formula C25H23FN8O2S2 M. Wt 550.63
  • Biological Activity
Description SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity. Upon intravenous administration, SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. SAR125844 displayed nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and the M1250T and Y1235D mutants. Broad biochemical profiling revealed that SAR125844 was highly selective for MET kinase. SAR125844 inhibits MET autophosphorylation in cell-based assays in the nanomolar range, and promotes low nanomolar proapoptotic and antiproliferative activities selectively in cell lines with MET gene amplification or pathway addiction.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets c Met 

Structure

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