SAR125844
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1116743-46-4 | Cat. No. | BCP28183 |
| Name | SAR125844 | ||
| Synonyms | SAR 125844; SAR-125844; | ||
| SMILES | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 | ||
| Chemical Name | |||
| Formula | C25H23FN8O2S2 | M. Wt | 550.63 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity. Upon intravenous administration, SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. SAR125844 displayed nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and the M1250T and Y1235D mutants. Broad biochemical profiling revealed that SAR125844 was highly selective for MET kinase. SAR125844 inhibits MET autophosphorylation in cell-based assays in the nanomolar range, and promotes low nanomolar proapoptotic and antiproliferative activities selectively in cell lines with MET gene amplification or pathway addiction. | ||
Recommend Products
More >
-
SOMG-833 HCl
Cat. No.：BCP49025
No.：1268264-10-3
Product Details -
Fosgonimeton
Cat. No.：BCP46997
No.：2093305-05-4
Product Details -
Ningetinib
Cat. No.：BCP46143
No.：1394820-69-9
Product Details -
JNJ-38877605
Cat. No.：BCP44121
No.：943540-74-7
Product Details -
-
PF-04217903 phenolsulfonate
Cat. No.：BCP36115
No.：1159490-85-3
Product Details -
S49076 HCl
Cat. No.：BCP35053
No.：1265965-19-2
Product Details -
Bozitinib
Cat. No.：BCP34901
No.：1440964-89-5
Product Details -
TAS-115 mesylate
Cat. No.：BCP34015
No.：1688673-09-7
Product Details -
-
Glumetinib
Cat. No.：BCP31155
No.：1642581-63-2
Product Details -
S49076 HCl
Cat. No.：BCP29576
No.：1265966-31-1
Product Details -
Sitravatinib
Cat. No.：BCP29099
No.：1123837-84-2
Product Details -
Ensartinib dihydrochloride
Cat. No.：BCP29059
No.：2137030-98-7
Product Details -
Ensartinib
Cat. No.：BCP26265
No.：1370651-20-9
Product Details -
BMS817378
Cat. No.：BCP15910
No.：1174161-69-3
Product Details -
-
-
-
Tags:SAR125844 supplier,SAR125844 purchase,SAR125844 manufacturer,SAR125844 distributor,SAR125844 cost,SAR125844 buy,SAR125844 for sale