AMG-837 calcium hydrate

CAS No.	1259389-38-2	Cat. No.	BCP28243
Name	AMG-837 calcium hydrate
Synonyms	AMG837 calcium hydrate；AMG 837 calcium hydrate；AMG837; AMG-837; AMG 837;
Formula	C52H42CaF6O7	M. Wt	932.97

Description	AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes.
Pathways	Hormone Pathay GPCR/G Protein
Targets	GPR

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