AMG-837 calcium hydrate New
Data Sheet
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| CAS No. | 1259389-38-2 | Cat. No. | BCP28243 |
| Name | AMG-837 calcium hydrate | ||
| Synonyms | AMG837 calcium hydrate；AMG 837 calcium hydrate；AMG837; AMG-837; AMG 837; | ||
| SMILES | CC#C[C@@H](CC([O-])=O)C1=CC=C(C=C1)OCC2=CC(C3=CC=C(C=C3)C(F)(F)F)=CC=C2.CC#C[C@@H](CC([O-])=O)C4=CC=C(C=C4)OCC5=CC(C6=CC=C(C=C6)C(F)(F)F)=CC=C5.[H]O[H].[Ca+2] | ||
| Chemical Name | |||
| Formula | C52H42CaF6O7 | M. Wt | 932.97 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes. | ||
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