AMG-837 calcium hydrate
| CAS号 | 1259389-38-2 | 货号 | BCP28243 |
| 中文名 | AMG-837 calcium hydrate | ||
| 英文名 | AMG-837 calcium hydrate | ||
| 中文别名 | |||
| 英文别名 | AMG837 calcium hydrate；AMG 837 calcium hydrate；AMG837; AMG-837; AMG 837; | ||
| 分子式 | C52H42CaF6O7 | 分子量 | 932.97 |
| 生物活性 | AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes. | ||
| 信号通路 | GPCR/G Protein Hormone Pathay | ||
| 靶 点 | GPR | ||
结构式
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