AMG-837 calcium hydrate 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP28243CAS号：1259389-38-2纯度：98%

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CAS号	1259389-38-2	货号	BCP28243
中文名	AMG-837 calcium hydrate
英文名	AMG-837 calcium hydrate
中文别名
英文别名	AMG837 calcium hydrate；AMG 837 calcium hydrate；AMG837; AMG-837; AMG 837;
SMILES	CC#C[C@@H](CC([O-])=O)C1=CC=C(C=C1)OCC2=CC(C3=CC=C(C=C3)C(F)(F)F)=CC=C2.CC#C[C@@H](CC([O-])=O)C4=CC=C(C=C4)OCC5=CC(C6=CC=C(C=C6)C(F)(F)F)=CC=C5.[H]O[H].[Ca+2]
化学名称
分子式	C52H42CaF6O7	分子量	932.97
纯度	98%	配送	惯例下常温包邮
产品描述	AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes.