NMS-P715
| CAS No. | 1202055-32-0 | Cat. No. | BCP28244 |
| Name | NMS-P715 | ||
| Synonyms | NMSP715; NMSP 715; | ||
| Formula | C35H39F3N8O3 | M. Wt | 676.73 |
| Description | NMS-P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Mps1 | ||
Structure
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