NMS-P715 New
Data Sheet
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| CAS No. | 1202055-32-0 | Cat. No. | BCP28244 |
| Name | NMS-P715 | ||
| Synonyms | NMSP715; NMSP 715; | ||
| SMILES | O=C(C1=NN(C)C2=C1CCC3=CN=C(NC4=CC=C(C(NC5CCN(C)CC5)=O)C=C4OC(F)(F)F)N=C23)NC6=C(CC)C=CC=C6CC | ||
| Chemical Name | |||
| Formula | C35H39F3N8O3 | M. Wt | 676.73 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NMS-P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells. | ||
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