RX3117
| CAS No. | 865838-26-2 | Cat. No. | BCP10720 |
| Name | RX3117 | ||
| Synonyms | RX-3117;RX 3117; TV1360; TV1360; TV 1360; Fluorocyclopentenylcytosine; | ||
| Formula | C10H12FN3O4 | M. Wt | 257.22 |
| Description | RX-3117, also known as TV-1360, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Antimetabolite | ||
Structure
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