ISRIB (cis-isomer)
| CAS No. | 548470-11-7 | Cat. No. | BCP10786 |
| Name | ISRIB (cis-isomer) | ||
| Synonyms | cis-ISRIB;ISRIB; | ||
| Formula | C22H24Cl2N2O4 | M. Wt | 451.34 |
| Description | ISRIB is a potent inhibitor of PERK signaling.trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PERK | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.