ISRIB (cis-isomer) New
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| CAS No. | 548470-11-7 | Cat. No. | BCP10786 |
| Name | ISRIB (cis-isomer) | ||
| Synonyms | cis-ISRIB;ISRIB; | ||
| SMILES | O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3 | ||
| Chemical Name | |||
| Formula | C22H24Cl2N2O4 | M. Wt | 451.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ISRIB is a potent inhibitor of PERK signaling.trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. | ||
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