NMS-P715 analog
| CAS号 | 1202055-34-2 | 货号 | BCP28300 |
| 中文名 | NMS-P715 analog | ||
| 英文名 | NMS-P715 analog | ||
| 中文别名 | |||
| 英文别名 | NMSP-715; NMSP715; NMSP 715; | ||
| 分子式 | C35H42N8O3 | 分子量 | 622.76 |
| 生物活性 | NMS-P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Mps1 | ||
结构式
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