Valacyclovir

CAS No.	124832-26-4	Cat. No.	BCP28415
Name	Valacyclovir
Synonyms	Valaciclovir;Val-ACV; Valtrex; Zelitrex;
Formula	C13H20N6O4	M. Wt	324.34

Description	Valacyclovir, also known as valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. Valaciclovir has been available as a generic drug in the U.S. since November 25, 2009. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase.
Pathways	Microbiology/Virology
Targets	HSV

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