Valacyclovir
Data Sheet
For research use only. Not for human use.
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| CAS No. | 124832-26-4 | Cat. No. | BCP28415 |
| Name | Valacyclovir | ||
| Synonyms | Valaciclovir;Val-ACV; Valtrex; Zelitrex; | ||
| SMILES | O=C(N1)C2=C(N=C1N)N(COCCOC([C@@H](N)C(C)C)=O)C=N2 | ||
| Chemical Name | |||
| Formula | C13H20N6O4 | M. Wt | 324.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Valacyclovir, also known as valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. Valaciclovir has been available as a generic drug in the U.S. since November 25, 2009. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase. | ||
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