甲氧苄啶
| CAS号 | 738-70-5 | 货号 | BCP12148 |
| 中文名 | 甲氧苄啶 | ||
| 英文名 | Trimethoprim | ||
| 中文别名 | |||
| 英文别名 | Trimpex;Proloprim; | ||
| 分子式 | C14H18N4O3 | 分子量 | 290.32 |
| 生物活性 | Trimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthetase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug c | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DHFR | ||
结构式
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