甲氧苄啶

参考资料仅供科学研究，不可用于个人用途。

货号：BCP12148CAS号：738-70-5纯度：98%

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CAS号	738-70-5	货号	BCP12148
中文名	甲氧苄啶
英文名	Trimethoprim
中文别名
英文别名	Trimpex;Proloprim;
SMILES
化学名称
分子式	C14H18N4O3	分子量	290.32
纯度	98%	配送	惯例下常温包邮
产品描述	Trimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthetase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug c